Fractionation of a Three‐Particle Mixture by Brownian Sieving Hydrodynamic Chromatography

نویسندگان

چکیده

Particles ranging in size from a few nanometers (exosomes or viruses) to micrometers (bacteria red blood cells) can be sorted using size-based separation process. One of the simplest techniques is provided by hydrodynamic chromatography (HDC) which typically requires long channels achieve adequate resolution. A new mechanism based on Brownian sieving effect coupled with HDC has recently been proposed overcome these limitations. An efficiency improvement up 2000 % predicted for two-size mixture. The aim this work study and optimize modified geometry useful obtaining simultaneous three-size diluted suspension. results suggest significant performance improvement, 3000 %, over standard HDC.

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ژورنال

عنوان ژورنال: Chemical Engineering & Technology

سال: 2023

ISSN: ['0930-7516', '1521-4125']

DOI: https://doi.org/10.1002/ceat.202200490